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. Author manuscript; available in PMC: 2018 Apr 30.
Published in final edited form as: J Med Chem. 2016 Mar 28;59(7):3140–3151. doi: 10.1021/acs.jmedchem.5b01912

Table 1.

In Vitro Antibacterial Activity (MIC99) of Diamines Tested against S. aureus RN4220, P. aeruginosa PAO1, and E. coli ANS1a

Compound Chemical Structure MIC99 (μg/ml)
S. aureus RN4220 P. aeruginosa PAOI E. coli ANSI
1 graphic file with name nihms960642t1.jpg 32 ± 2.4 256 ±6.3 32 ±3.3
2 graphic file with name nihms960642t2.jpg 6.7 ±2.3 13.3 ±4.6 6 ±2.8
3 graphic file with name nihms960642t3.jpg 2 ±0.8 8 ± 1.6 2± 1.1
4 graphic file with name nihms960642t4.jpg 9.3±6.1 32 ±5.2 10 ±8.5
5 graphic file with name nihms960642t5.jpg >256 >256 >256
6 graphic file with name nihms960642t6.jpg 106.7±37.3 213.3±73.9 64 ±8.6
7 graphic file with name nihms960642t7.jpg 10.7±4.6 13.3±4.6 6 ±2.8
8 graphic file with name nihms960642t8.jpg 18.7±12.2 26.7+9.2 4 ±0.8
9 graphic file with name nihms960642t9.jpg 13.3±4.6 26.7±9.2 6 ±2.8
10 graphic file with name nihms960642t10.jpg 3.8 ±2.9 10.4 ±3.3 6.2 ± 1.8
11 graphic file with name nihms960642t11.jpg 11.3 ±3.7 18.6 ±5.8 4.4 ±2.6
12 graphic file with name nihms960642t12.jpg 4.9 ± 1.3 29.2 ±2.2 10.4 ±3.7
13 graphic file with name nihms960642t13.jpg >256 >256 >256
14 graphic file with name nihms960642t14.jpg >256 >256 >256
15 graphic file with name nihms960642t15.jpg >256 >256 >256
16 graphic file with name nihms960642t16.jpg >256 >256 >256
Spermine >512 >512 >512
Spermidine >512 >512 >512
Ampicillin 0.125 ±0.7 128 ±4.3 -
Kanamycin 8 ± 1.1 32 ±3.8 8 ±3.3
Norfloxacin 0.5 ±0.6 0.5 ± 02 0.25 ± 0.8
Colistin >16 <0.125 ND
a

MIC99 values were determined three times independently and are presented as averages ± standard deviation (SD). ND = not determined.