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. Author manuscript; available in PMC: 2018 Apr 30.
Published in final edited form as: Mol Pharm. 2017 Sep 26;14(11):3815–3823. doi: 10.1021/acs.molpharmaceut.7b00559

Figure 1.

Figure 1

Schematic representation of TMV-PEG8/28-STK particle synthesis. (A) Functionalization of TMV-Lys particles with maleimide groups. (B) Labeling STK molecules with thiol groups. (C) Bioconjugation of STK-PEG4-SH ligands to TMV-PEG4/24-maleimide particle to form final TMV-PEG8/28-STK particles. TMV’s structural data46 (ID: 2TMV) and STK’s structural data47 (ID: 1BML) obtained from the Protein Data Bank (PDB) were used to represent these components using UCSF Chimera software.44 Note that the TMV fragment and STK structures are not shown on the same scale.