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. Author manuscript; available in PMC: 2018 Apr 30.
Published in final edited form as: Mol Pharm. 2017 Sep 26;14(11):3815–3823. doi: 10.1021/acs.molpharmaceut.7b00559

Figure 4.

Figure 4

Static in vitro assay of thrombolytic activity: phantom clot dissolution. (A) Image of phantom clots 20 h after application of STK and TMV-PEG8/28-STK solutions. The dark colored circular areas result from dissolution of fibrin clot by STK. Samples were applied in triplicates. (B) Area-of-dissolution analysis of image (A). Data were analyzed using Student’s t test (2-tailed, unpaired); statistically significant differences are indicated by ****p ≤ 0.0001, ***p ≤ 0.001, *p ≤ 0.05. No statistically significant differences were found between TMV-PEG8-STK and TMV-PEG28-STK samples of corresponding concentrations.