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. 2018 Feb 6;9(3):137–151. doi: 10.1080/21541264.2018.1429837

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — A strong negative selection against adenine in the anticodon wobble position. The homologous T loop is shown below the anticodon (Ac) loop for comparison. DNA sequence logos of the 7 nt anticodon and T loops are shown. Right panels) In archaea (1088 tRNAs), no A is detected at the anticodon wobble position. Left panels) In bacteria (6368 tRNAs), adenine (A) is rarely used, except in tRNA^Arg (anticodon ACG), and adenine is converted to inosine (I) by tRNA adenosine deaminase [12]. Blue dots indicate the anticodon positions of the loop. The asterisk indicates the wobble position of the anticodon loop.