Figure 5.

NEAT1 reversed the inhibitory effect of let-7a-5p on the cisplatin resistance of NPC cells. MTT assay was used to assess cell viability in S18 (A) and 5–8F (B) cells stably transfected with let-7a-5p alone or combined with pcDNA-NEAT1, following exposure to 10 μg/ml cisplatin for 48 h. EdU assay was performed to detect the cell proliferation in S18 (C) and 5–8F (D) cells transfected with let-7a-5p or pcDNA-NEAT1, following treatment with 10 μg/ml cisplatin for 48 h. *P < 0.05, **P < 0.01, and ***P < 0.001.