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Activation of GPER modulated the activities of MPAK and PI3K/AKT signals. (A) ACHN cells were treated with 1 μM G-1 for the indicated times, and then the activation of AKT, ERK, p38-MAPK and JNK were examined by Western blot analysis; (B) OS-RC-2 cells were treated with 1 μM G-1 for the indicated times, and then the activation of AKT, ERK, p38-MAPK and JNK were examined by Western blot analysis. Data represent at least three independent experiments.
