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After damage, MuSCs activate, proliferate and differentiate or self-renew. While inhibition of AMPKα1 triggers the cells to self-renew by up-regulating the Lactate Dehydrogenase (LDH) activity and glycolysis; down-regulation of the OXPHOS and in general the mitochondrial activity, activate AMPKα1 and leads MuSC to differentiate.
