Table 3.
OR and 95%CI of six treatment modalities of six hematologic endpoint outcomes.
| OR (95%CI) | |||||
|---|---|---|---|---|---|
| Hematologic (all grades) | |||||
| Anemia | |||||
| A | 0.14 (0.00, 8.15) | 1.17 (0.02, 81.35) | 0.02 (0.00, 2.03) | 1.09 (0.02, 69.54) | |
| 7.16 (0.12, 572.91) | B | 8.60 (0.02, 3494.09) | 0.18 (0.00, 82.00) | 7.97 (0.02, 3123.86) | |
| 0.85 (0.01, 65.16) | 0.12 (0.00, 44.41) | C | 0.02 (0.00, 8.45) | 0.92 (0.00, 342.54) | |
| 43.12 (0.49, 4169.92) | 5.68 (0.01, 2891.05) | 47.49 (0.12, 27841.94) | D | 45.57 (0.11, 22388.71) | |
| 0.92 (0.01, 59.19) | 0.13 (0.00, 44.59) | 1.08 (0.00, 462.62) | 0.02 (0.00, 9.31) | G | |
| Neutropenia | |||||
| A | 0.38 (0.04, 3.49) | 1.10 (0.11, 11.19) | 0.13 (0.01, 1.50) | 1.27 (0.13, 12.42) | |
| 2.63 (0.29, 24.32) | B | 2.90 (0.12, 73.62) | 0.34 (0.01, 8.66) | 3.33 (0.13, 89.14) | |
| 0.91 (0.09, 8.88) | 0.34 (0.01, 8.51) | C | 0.12 (0.00, 3.19) | 1.16 (0.05, 29.09) | |
| 7.66 (0.67, 99.25) | 2.94 (0.12, 94.27) | 8.52 (0.31, 278.91) | D | 10.05 (0.38, 306.85) | |
| 0.79 (0.08, 8.00) | 0.30 (0.01, 7.45) | 0.86 (0.03, 22.05) | 0.10 (0.00, 2.65) | G | |
| Thrombocytopenia | |||||
| A | 0.40 (0.12, 1.40) | 1.88 (0.55, 6.38) | 1.49 (0.37, 6.22) | 1.28 (0.41, 4.07) | |
| 2.50 (0.71, 8.53) | B | 4.71 (0.81, 26.25) | 3.76 (0.60, 24.32) | 3.20 (0.59, 17.18) | |
| 0.53 (0.16, 1.82) | 0.21 (0.04, 1.23) | C | 0.81 (0.13, 5.22) | 0.68 (0.13, 3.92) | |
| 0.67 (0.16, 2.69) | 0.27 (0.04, 1.66) | 1.24 (0.19, 7.99) | D | 0.87 (0.14, 4.96) | |
| 0.78 (0.25, 2.45) | 0.31 (0.06, 1.68) | 1.46 (0.25, 7.73) | 1.15 (0.20, 7.12) | G | |
| Hematologic (grade≥3) | |||||
| Anemia | |||||
| A | 0.08 (0.00, 1.87) | 2.32 (0.15, 37.97) | 0.08 (0.00, 1.71) | 0.58 (0.03, 9.64) | 1.22 (0.09, 18.18) |
| 12.62 (0.53, 581.06) | B | 30.19 (0.48, 3188.84) | 1.07 (0.01, 136.24) | 7.51 (0.12, 829.90) | 16.98 (0.27, 1652.03) |
| 0.43 (0.03, 6.49) | 0.03 (0.00, 2.10) | C | 0.03 (0.00, 2.06) | 0.25 (0.00, 12.43) | 0.56 (0.01, 24.31) |
| 12.03 (0.59, 268.43) | 0.93 (0.01, 81.93) | 29.80 (0.49, 1710.19) | D | 7.10 (0.11, 365.84) | 14.92 (0.28, 901.17) |
| 1.72 (0.10, 28.67) | 0.13 (0.00, 8.29) | 4.08 (0.08, 213.72) | 0.14 (0.00, 8.80) | E | 2.26 (0.04, 106.91) |
| 0.82 (0.06, 11.62) | 0.06 (0.00, 3.73) | 1.79 (0.04, 101.93) | 0.07 (0.00, 3.60) | 0.44 (0.01, 23.35) | G |
| Neutropenia | |||||
| A | 0.46 (0.17, 1.39) | 1.16 (0.39, 3.38) | 0.90 (0.27, 2.67) | 1.11 (0.39, 2.98) | 1.45 (0.51, 3.89) |
| 2.17 (0.72, 6.05) | B | 2.44 (0.52, 11.47) | 1.92 (0.37, 8.51) | 2.36 (0.53, 9.90) | 3.13 (0.67, 12.77) |
| 0.86 (0.30, 2.56) | 0.41 (0.09, 1.91) | C | 0.75 (0.15, 3.62) | 0.92 (0.23, 4.26) | 1.29 (0.28, 5.46) |
| 1.11 (0.37, 3.66) | 0.52 (0.12, 2.67) | 1.34 (0.28, 6.48) | D | 1.20 (0.28, 5.93) | 1.69 (0.37, 7.62) |
| 0.90 (0.34, 2.55) | 0.42 (0.10, 1.90) | 1.09 (0.23, 4.44) | 0.84 (0.17, 3.53) | E | 1.37 (0.30, 5.33) |
| 0.69 (0.26, 1.97) | 0.32 (0.08, 1.50) | 0.78 (0.18, 3.52) | 0.59 (0.13, 2.67) | 0.73 (0.19, 3.30) | G |
| Thrombocytopenia | |||||
| A | 0.53 (0.12, 2.03) | 0.89 (0.26, 3.13) | 0.43 (0.11, 1.72) | 0.95 (0.28, 3.04) | 1.29 (0.39, 4.23) |
| 1.89 (0.49, 8.66) | B | 1.69 (0.29, 12.58) | 0.82 (0.13, 6.31) | 1.82 (0.29, 12.47) | 2.53 (0.42, 16.83) |
| 1.12 (0.32, 3.80) | 0.59 (0.08, 3.46) | C | 0.48 (0.07, 3.01) | 1.05 (0.19, 5.84) | 1.45 (0.26, 7.95) |
| 2.35 (0.58, 9.38) | 1.22 (0.16, 7.98) | 2.09 (0.33, 14.01) | D | 2.23 (0.35, 13.74) | 3.02 (0.49, 18.93) |
| 1.05 (0.33, 3.52) | 0.55 (0.08, 3.46) | 0.96 (0.17, 5.33) | 0.45 (0.07, 2.86) | E | 1.37 (0.26, 7.53) |
| 0.77 (0.24, 2.55) | 0.40 (0.06, 2.36) | 0.69 (0.13, 3.90) | 0.33 (0.05, 2.04) | 0.73 (0.13, 3.87) | G |
Notes: OR and 95%CI below the treatments should be read from row to column while above the treatments should be read from column to row. OR = odds ratio; 95%CI = 95% confidence intervals; A = Gemcitabine+Placebo; B = Gemcitabine+Axitinib; C = Gemcitabine+Trametinib; D = Gemcitabine+Sorafenib; E = Gemcitabine+Bevacizumab; G = Gemcitabine+Tipifarnib.