Table 4.
OR and 95%CI of six treatment modalities of six non-hematologic endpoint outcomes.
| OR (95%CI) | |||||
|---|---|---|---|---|---|
| Non-hematologic (all grades) | |||||
| Rash | |||||
| A | 0.29 (0.06, 1.36) | 2.71 (0.57, 13.27) | 2.99 (0.67, 14.14) | 1.23 (0.24, 6.52) | |
| 3.50 (0.74, 17.16) | B | 9.36 (1.02, 92.76) | 10.33 (1.26, 90.71) | 4.21 (0.45, 41.90) | |
| 0.37 (0.08, 1.76) | 0.11 (0.01, 0.98) | C | 1.08 (0.12, 10.36) | 0.44 (0.05, 4.68) | |
| 0.33 (0.07, 1.50) | 0.10 (0.01, 0.79) | 0.93 (0.10, 8.41) | F | 0.41 (0.04, 3.77) | |
| 0.81 (0.15, 4.14) | 0.24 (0.02, 2.21) | 2.25 (0.21, 21.84) | 2.47 (0.27, 24.25) | G | |
| Diarrhea | |||||
| A | 0.42 (0.01, 26.80) | 3.15 (0.05, 208.59) | 64.04 (0.61, 7704.44) | 1.41 (0.02, 82.20) | 1.58 (0.03, 88.60) |
| 2.39 (0.04, 131.89) | B | 7.39 (0.02, 2343.83) | 148.77 (0.31, 79234.08) | 3.32 (0.01, 948.13) | 3.80 (0.01, 1189.69) |
| 0.32 (0.00, 19.63) | 0.14 (0.00, 41.70) | C | 20.62 (0.04, 10762.48) | 0.47 (0.00, 140.96) | 0.50 (0.00, 173.64) |
| 0.02 (0.00, 1.63) | 0.01 (0.00, 3.27) | 0.05 (0.00, 26.26) | D | 0.02 (0.00, 12.55) | 0.02 (0.00, 10.07) |
| 0.71 (0.01, 45.20) | 0.30 (0.00, 114.65) | 2.15 (0.01, 795.46) | 46.81 (0.08, 25274.19) | F | 1.12 (0.00, 345.72) |
| 0.63 (0.01, 37.35) | 0.26 (0.00, 91.23) | 1.99 (0.01, 692.07) | 41.16 (0.10, 18905.66) | 0.89 (0.00, 294.60) | G |
| Stomatitis | |||||
| A | 1.48 (0.05, 54.85) | 6.13 (0.18, 221.89) | 19.76 (0.46, 798.39) | 1.64 (0.05, 57.51) | |
| 0.68 (0.02, 22.11) | B | 4.17 (0.03, 610.35) | 13.37 (0.07, 2238.47) | 1.11 (0.01, 156.96) | |
| 0.16 (0.00, 5.56) | 0.24 (0.00, 34.47) | C | 3.21 (0.02, 611.15) | 0.27 (0.00, 39.83) | |
| 0.05 (0.00, 2.16) | 0.07 (0.00, 13.80) | 0.31 (0.00, 50.19) | D | 0.08 (0.00, 11.77) | |
| 0.61 (0.02, 21.86) | 0.90 (0.01, 146.27) | 3.73 (0.03, 577.73) | 12.03 (0.08, 2208.64) | F | |
| Non-hematologic (grade≥3) | |||||
| Rash | |||||
| A | 0.99 (0.08, 11.05) | 6.81 (0.46, 292.28) | 9.07 (0.62, 370.88) | 2.30 (0.12, 97.36) | |
| 1.01 (0.09, 12.15) | B | 7.28 (0.16, 533.29) | 9.84 (0.23, 733.82) | 2.37 (0.06, 192.09) | |
| 0.15 (0.00, 2.18) | 0.14 (0.00, 6.15) | C | 1.38 (0.01, 110.68) | 0.35 (0.00, 35.15) | |
| 0.11 (0.00, 1.61) | 0.10 (0.00, 4.26) | 0.73 (0.01, 70.12) | F | 0.24 (0.00, 24.51) | |
| 0.44 (0.01, 8.54) | 0.42 (0.01, 17.58) | 2.86 (0.03, 305.85) | 4.19 (0.04, 419.48) | G | |
| Diarrhea | |||||
| A | 0.11 (0.00, 1.60) | 8.64 (0.62, 370.49) | 0.63 (0.06, 5.82) | 3.51 (0.32, 55.29) | 1.32 (0.13, 15.29) |
| 9.10 (0.63, 526.96) | B | 91.68 (1.78, 13496.48) | 5.80 (0.18, 652.52) | 33.71 (0.86, 3857.15) | 12.35 (0.32, 1109.38) |
| 0.12 (0.00, 1.61) | 0.01 (0.00, 0.56) | C | 0.07 (0.00, 2.38) | 0.39 (0.01, 17.62) | 0.15 (0.00, 5.27) |
| 1.60 (0.17, 15.69) | 0.17 (0.00, 5.66) | 15.23 (0.42, 1064.71) | D | 5.86 (0.20, 192.49) | 2.18 (0.08, 61.23) |
| 0.28 (0.02, 3.16) | 0.03 (0.00, 1.16) | 2.58 (0.06, 187.55) | 0.17 (0.01, 4.95) | F | 0.37 (0.01, 12.76) |
| 0.76 (0.07, 7.77) | 0.08 (0.00, 3.11) | 6.86 (0.19, 513.41) | 0.46 (0.02, 12.78) | 2.72 (0.08, 92.84) | G |
| Stomatitis | |||||
| A | 0.92 (0.02, 33.25) | 2.44 (0.13, 96.04) | 5.59 (0.42, 224.30) | 0.85 (0.02, 28.95) | |
| 1.09 (0.03, 46.55) | B | 2.79 (0.02, 455.98) | 7.23 (0.06, 925.05) | 0.90 (0.00, 178.08) | |
| 0.41 (0.01, 7.73) | 0.36 (0.00, 41.16) | C | 2.26 (0.03, 238.49) | 0.30 (0.00, 37.95) | |
| 0.18 (0.00, 2.35) | 0.14 (0.00, 17.48) | 0.44 (0.00, 33.19) | D | 0.14 (0.00, 12.52) | |
| 1.18 (0.03, 51.95) | 1.11 (0.01, 220.96) | 3.36 (0.03, 728.13) | 7.36 (0.08, 1096.69) | F | |
Notes: OR and 95%CI below the treatments should be read from row to column while above the treatments should be read from column to row. OR = odds ratio; 95%CI = 95% confidence intervals; A = Gemcitabine+Placebo; B = Gemcitabine+Axitinib; C = Gemcitabine+Trametinib; D = Gemcitabine+Sorafenib; F = Gemcitabine+Erlotinib; G = Gemcitabine+Tipifarnib.