Figure 3.

(a) The interaction model between HIV-1 RT (reverse transcriptase) and the aptamer. The secondary structure of aptamer is the -HIV-1 RT complex. The p66 subdomains: fingers, palm, thumb, and RNase H and p51 interactions are shown using a surface representation (With permission of Springer) [ref 124]. (b) The dimeric 93del aptamer is positioned into the channel formed by the HIV1-IN (integrase) tetramer to block the HIV1-IN catalytic site (reproduced with permission from Proceedings of the National Academy of Sciences USA) [ref 134].