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. 2018 Apr 20;7:e32866. doi: 10.7554/eLife.32866

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© 2018, McLelland et al

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Figure 9. — (A) PINK1-phosphorylated Ub on Mfn2 initially recruits parkin to Mfn2 complexes, where it is phosphorylated and activated by PINK1. (B) Parkin and PINK1 cooperate to catalyze a pUb burst on Mfn2. (C) Ubiquitinated Mfn2 HMW complexes are recognized by p97, which translocates to mitochondria. (D) Ubiquitinated Mfn2 is retrotranslocated from the OMM and degraded by the proteasome. (E) VDACs and possibly other substrates become available to the parkin/PINK1 system, and their phosphoubiquitination stabilizes parkin on mitochondria to drive mitophagy.