Table 3.
Survival Concordance Probability With SE, Hazard Ratio With 95% CI, and Unadjusted P Value From LRT for the Univariate and Multivariate Analyses
| Analysis | Marker | Concordance Probability (SE) | Hazard Ratio (95% CI) | LRT P |
|---|---|---|---|---|
| Univariate Analysis (NSCLC and SCLC) | TNFα ≤ BLQ | 0.60 (0.04) | 2.27 (1.22-4.23) | .008 |
| IL-1b ≤ BLQ | 0.65 (0.04) | 4.02 (2.04-7.93) | <.001 | |
| KGF ≤ BLQ | 0.51 (0.03) | 1.16 (0.63-2.11) | .639 | |
| IL-12 ≤ BLQ | 0.56 (0.04) | 2.00 (1.05-3.82) | .030 | |
| Neutrophilsa | 0.60 (0.05) | 1.07 (1.02-1.11) | .017 | |
| Lymphocytesa | 0.48 (0.05) | 1.03 (0.97-1.09) | .410 | |
| Neutrophil to lymphocyte ratio | 0.58 (0.05) | 1.02 (0.98-1.06) | .396 | |
| Final Baseline Model (NSCLC Only) | IL-1b ≤ BLQ | 0.67 (0.05) | <.001 | |
| IL-1b ≤ BLQ + neutrophils | 0.74 (0.06) | .042 | ||
| IL-1b ≤ BLQ | 4.62 (2.11-10.14) | |||
| Neutrophilsa | 1.07 (1.01-1.14) |
Blood marker thresholds were on the basis of their respective BLQ values. Statistically significant values are shown in bold.
Abbreviations: BLQ = below limit of quantification; IL = interleukin; KGF = keratinocyte growth factor; LRT = likelihood ratio test; NSCLC = non–small-cell lung cancer; SCLC = small-cell lung cancer; TNF = tumor necrosis factor.
a
Continuous variable; the higher the neutrophils the worse the survival.