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. Author manuscript; available in PMC: 2019 Mar 7.
Published in final edited form as: Neuron. 2018 Mar 7;97(5):1032–1048.e5. doi: 10.1016/j.neuron.2018.02.002

Figure 4. Increased TREM2 gene dosage reprogrammed disease-associated microglia gene expression.

Figure 4

(A) Heatmap representation of differential expression Z statistics for TD1-3 genes. Genes are divided into TD1 (blue), TD2 (green) and TD3 (red).

(B–C) Fold changes of individual TD1 (B) and TD2 (C) genes in 5xFAD (red) and 5xFAD/TREM2 (blue) vs. wildtype mice at 7m. Stars indicate FDR-corrected significance (***FDR<0.001, **FDR<0.01, *FDR<0.1). n=6 per genotype, except n=5 for 5xFAD.

(D–F) Venn diagrams of overlaps of TD1 (blue) and TD2 (green) genes with published genesets (orange).