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. Author manuscript; available in PMC: 2019 Mar 7.
Published in final edited form as: Neuron. 2018 Mar 7;97(5):1032–1048.e5. doi: 10.1016/j.neuron.2018.02.002

Figure 7. Increase TREM2 gene dosage in microglia reduced plaque-associated neuritic pathology and ameliorate cognitive deficit.

Figure 7

(A–D) Representative images of APP-immunolabeled dystrophic neurites (red) surrounding the plaques co-labelled with 4G8 (purple) and thioflavin S (green) in the cortex of 5xFAD and 5xFAD/TREM2 mice. Bar = 25μm.

(E) Total dystrophy neurites volume was quantified in the cortex of 5xFAD and 5xFAD/TREM2 mice. n = 3 per genotype. Data presented as mean ± SEM, **p < 0.01. (F) The contextual memory function of mice from the cohort of BAC-TREM2 × 5xFAD (n = 8–14 per genotype) was evaluated by contextual fear conditioning and is presented as percent time freezing. Power analysis was performed to ensure >80% confidence levels with the number of animals used. **p < 0.01, *p < 0.05.