TABLE 1.
Trial Outcomes By Treatment Assignment for Aortic Measurements
| Baseline | 3 Years | Annual Rate of Change (Slope ± Standard Error) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Variables | n | Atenolol | n | Losartan | p | n | Atenolol | n | Losartan | Atenolol | Losartan | p* |
| Aortic-root diameter z-score | 303 | 4.2 ± 1.2 | 304 | 4.4 ± 1.5 | 0.68 | 268 | 3.7 ± 1.3 | 267 | 3.9 ± 1.5 | −0.139 ± 0.013 | −0.107 ± 0.013 | 0.08 |
| Aortic-root diameter (cm) | 303 | 3.4 ± 0.7 | 304 | 3.4 ± 0.7 | 0.96 | 268 | 3.5 ± 0.7 | 267 | 3.5 ± 0.6 | 0.069 ± 0.004 | 0.075 ± 0.004 | 0.20 |
| Ascending-aorta diameter z-score | 263 | 0.9 ± 0.9 | 280 | 1.1 ± 1.1 | 0.13 | 218 | 0.5 ± 0.8 | 236 | 0.6 ± 1.1 | −0.140 ± 0.013 | −0.114 ± 0.013 | 0.15 |
| Ascending-aorta diameter (cm) | 263 | 2.3 ± 0.5 | 280 | 2.3 ± 0.5 | 0.62 | 218 | 2.4 ± 0.4 | 236 | 2.4 ± 0.4 | 0.039 ± 0.004 | 0.044 ± 0.004 | 0.30 |
| Systolic blood pressure (mm Hg) | 303 | 97 ± 13 | 303 | 98 ± 12 | 0.53 | 268 | 95 ± 12 | 268 | 96 ± 13 | 0.108 ± 0.194 | 0.018 ± 0.195 | 0.73 |
| Diastolic blood pressure (mm Hg) | 303 | 59 ± 10 | 303 | 59 ± 8 | 0.46 | 268 | 54 ± 8 | 268 | 56 ± 8 | −0.919 ± 0.159 | −0.509 ± 0.160 | 0.05 |
| Mean blood pressure (mm Hg) | 298 | 72 ± 11 | 297 | 71 ± 9 | 0.61 | 266 | 68 ± 10 | 268 | 69 ± 9 | −0.574 ± 0.173 | −0.381 ± 0.173 | 0.40 |
| Systolic blood pressure z-score | 303 | −0.7 ±1.0* | 303 | −0.6 ± 1.0* | 0.29 | 268 | −1.1 ± 0.9* | 268 | −1.0 ± 1.0* | −0.070 ± 0.017 | −0.073 ± 0.017 | 0.90 |
| Diastolic blood pressure z-score | 303 | 0.3 ± 1.0* | 303 | 0.3 ± 0.9* | 0.59 | 268 | −0.3 ± 0.9* | 268 | −0.2 ± 0.8* | −0.155 ± 0.017 | −0.107 ± 0.017 | 0.03 |
| Mean blood pressure z-score | 298 | −0.2 ± 1.0* | 297 | −0.3 ± 0.9* | 0.84 | 266 | −0.8 ± 0.9* | 268 | −0.7 ± 0.9* | −0.117 ± 0.017 | −0.092 ± 0.017 | 0.27 |
| Aortic-root elastic modulus (mmHg) | 299 | 730 ± 511 | 299 | 792 ± 548 | 0.15 | 260 | 704 ± 504 | 262 | 774 ± 671 | −0.003 ± 9.745 | 14.1 ± 9.800 | 0.26 |
| Aortic-root stiffness index | 299 | 9.5 ± 6.3 | 299 | 10.3 ± 6.7 | 0.13 | 260 | 9.6 ± 6.5 | 262 | 10.4 ± 8.9 | 0.037 ± 0.128 | 0.219 ± 0.128 | 0.27 |
| Aortic-root stiffness index/√R-R interval | 299 | 10.7 ± 6.8 | 299 | 11.6 ± 7.4 | 0.13 | 260 | 9.8 ± 6.5 | 262 | 11.3 ± 9.3 | 0.298 ± 0.139 | 0.141 ± 0.139 | 0.01 |
| Ascending-aorta elastic modulus (mm Hg) | 237 | 362 ± 195 | 255 | 385 ± 223 | 0.24 | 192 | 382 ± 288 | 205 | 353 ± 192 | 12.584 ± 5.003 | 0.315 ± 4.913 | 0.05† |
| Ascending-aorta stiffness index | 237 | 4.8 ± 2.6 | 255 | 5.1 ± 2.9 | 0.29 | 192 | 5.2 ± 3.9 | 205 | 4.8 ± 2.4 | 0.184 ± 0.068 | 0.017 ± 0.067 | 0.05‡ |
| Ascending-aorta stiffness index/√R-R interval | 237 | 5.5 ± 3.3 | 255 | 5.8 ± 3.4 | 0.33 | 192 | 5.4 ± 4.0 | 205 | 5.2 ± 2.5 | 0.005 ± 0.075 | −0.046 ± 0.074 | 0.57 |
*
Linear model baseline-adjusted p value comparing slopes under compound symmetry.
Values are mean ± Standard deviation.
†
0.053
‡
0.047