Table 3. Significant clusters of FA-related differences between groups and correlations with clinical variables in PVD group.

FA Significant Clusters
Test	Cluster Number	Direction of Change	Cluster Size (mL)	COM Position (x, y, z)	Structures
PVD vs. HC	1	Increased	5.808	(-32, 17, 11.4)	Right sagittal stratum, cerebral peduncle, retrolenticular and posterior internal capsule, fornix/stria terminalis, external capsule, putamen, pallidum, thalamus, superior and anterior and posterior corona radiata, superior longitudinal fasciculus.
	2	Increased	1.074	(28.7, 41.7, 30.6)	Left posterior corona radiata, superior longitudinal fasciculus.
PVD vs. IBS	None

Statistical tests (both comparisons between groups and correlations with symptom variables) are listed. Clusters reported from largest to smallest. In ‘Direction of Change’, ‘Increased’ and ‘Decreased’ denote higher or lower values in PVD vs other group, respectively, while ‘Positive’ and ‘Negative’ denote increasing or decreasing value with increasing symptom score rating within PVD group only, respectively. Center of Mass (COM) coordinates given for MNI standard space. ‘Structures’ denote overlap of clusters with white matter ROIs from the JHU white matter atlas or subcortical gray matter ROIs from the Harvard-Oxford subcortical atlas, both available through FMRIB Software Library (FSL, https://fsl.fmrib.ox.ac.uk/fsl/fslwiki).

Abbreviations: HAD, Hospital Anxiety and Depression Scale; HC, Healthy Control; PVD, Provoked Vestibulodynia