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. 2018 Mar 15;103(5):908–918. doi: 10.3324/haematol.2017.184416

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Figure 1. — Antiphospholipid syndrome (APS) patients showed a specific circulating miRNAs profile related to clinical features of this autoimmune disorder. (A) To identify the changes that occurred in the expression levels of microRNAs (miR) in plasma from antiphospholipid syndrome versus controls, Human Serum & Plasma miRNA PCR-array (Qiagen) was performed in the study cohort. Expression levels of 19 miRNAs were found up-regulated in antiphospholipid syndrome, while 20 miRNAs were down-regulated. (B) Ingenuity Pathway Analysis (IPA) uncovered the main enriched biological functions and pathways in which these microRNAs are involved. The analysis included only the functions and pathways with average IPA score >2 [indicated as -log (P value)]. (C) Validation of selected miRNAs by RT-PCR in the whole cohort of APS patients and healthy donors. *P<0.05.