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. 2018 Mar 15;103(5):908–918. doi: 10.3324/haematol.2017.184416

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Figure 5. — Circulating miRNAs are related to clinical features of antiphospholipid syndrome (APS) and show potential as biomarkers for the development of atherosclerosis. Association studies of altered circulating microRNA (miRNA or miR) ratios and the occurrence of previous fetal loss (A), the type of thrombosis suffered (B) and the presence of a pathological carotid intima-media thickness (CIMT) (C). Beeswarm plot of each miR ratio is shown, along with mean, Standard Deviation, and P-value. (D) A combination as a panel of the 2 miRNA ratios associated to the pathological CIMT was carried out by using logistic regression on the data set and receiver operator characteristics (ROC) curve analyses were performed. ROC curve of miRNA panel and cut off were generated based on the predicted probability (P) for each patient as a single score. The equation used was: “Combined miRNA-ratio panel [Logit(p)] = 0.599 − 0.133x(miR-19b/miR-124) + 0.007x(miR-124/miR- 296)”. The area under the curve (AUC), sensitivity and specificity are shown, and a cut-off value with higher specificity was selected.