The frequencies of patients showing at least one mutation within genes grouped according to their functional properties. The gene groups were: epigenetic regulation (ASXL1, TET2, DNMT3A), splicing (SF3B1, SRSF2, U2AF1), the JAK-STAT pathway (JAK2, CALR, MPL) and the RAS pathway (NRAS, KRAS, CBL).