Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 1;9(5):493. doi: 10.1038/s41419-018-0535-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — Post transfection, the delayed cell motility was captured in a time-dependent manner in scratched A549 cells (a). Cell migration or invasion was measured after 48 h post transfection to allow for the permeabilization of the Trans-well membrane (b). Proteolytic enzyme activity of the secreted MMP-2 and -9 was analysed in the cultured soup for 48 h post transfection (c). The lung metastatic models that were injected with the miRNA mimic-transfected Fluc-stable A549 cells into the tail vein were grown for 5 weeks (n = 8 mice/group). After 5 weeks, the expressed Fluc signals visually show the degree of metastatic spread to lung, and Fluc signal intensity was quantified by ROI gates (d). Nodules generated on the lung surface (left) and histological staining (H&E) of lung tissues (right) visually show a distinct difference between each group (e) (bars, mean ± S.E.M.; *p < 0.05 and **p < 0.01)