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. 2018 Apr 30;8:6764. doi: 10.1038/s41598-018-24263-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The absence of letS leads to ectopic up-regulation of gene expression in water. (A) A heat map showing genes differentially expressed in ∆letS compared to the WT (left), and in OFF compared to ON (right) (ratio to control value of ± 2-fold with a p < 0.05). Genes that are up-regulated in ∆letS and OFF are shown in red; genes that are down-regulated are shown in green. The number of up- (B) or down-regulated (C) genes that are shared between the ∆letS vs. WT and OFF vs. ON groups are shown in Venn diagrams.