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. 2018 Apr 30;8:6758. doi: 10.1038/s41598-018-24509-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mtb infection augments M1 gene activation in M1 pre-activated macrophages. Using the differential expressed genes, qualitative analysis was performed in Mtb, IFNγ_Mtb, IL-4/IL-13_Mtb samples. Several fold elevated or suppressed genes were identified by calculating TMP expression fold change of IFNγ_Mtb in comparison with Mtb, IL-4/IL-13_Mtb samples at each time point. IFNγ pre-stimulation-mediated several fold up regulated (a) and suppressed or down regulated (b) non TF genes (10-fold respectively) and TF genes (3-fold respectively) was selected as seen in the heatmap cluster in each time point. Both heatmaps shows un-stimulated control which indicate the basal level of gene expression. (c) Expression profiles of representative M1 key effector genes, Nos2, Cxcl10, Cxcl9 and Cxcl11. (d) Expression profiles of representative M1 key TF genes, Batf2 and Irf1.