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. 2018 Apr 30;8:6755. doi: 10.1038/s41598-018-25133-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Permeabilization of SOPG LUVs by α-synuclein oligomers. (a) Fluorescently labelled LUVs premixed with oligomers were mixed with dithionite, causing a decrease of fluorescence as the dye was bleached by the dithionite (αS-1, green; αS-2, blue; αS-4, red; αS-8, yellow; PBS, black). Without α-synuclein present, only the outer leaflet was bleached; additional bleaching occurred in the presence α-synuclein of owing to bleaching of the inner leaflet after membrane permeabilization. (b) The percentage of membrane permeabilization 2 min after dithionite addition was calculated for each construct at different concentrations of α-synuclein and plotted as a function of the molar ratio of protein to lipid.