Table 3.
Correlations between alpha diversity measures, endothelial dysfunction and bacterial genes related to tryptophan metabolism, KT-ratio and inflammation in the total study population (n = 84) and the HIV-infected individuals with type 2 diabetes (n = 21).
| Variable | Gut microbiota diversity | Endothelial dysfunction | ||||||
|---|---|---|---|---|---|---|---|---|
| Observed species | Shannon Index | L-Arginine/ADMA | ADMA | |||||
| Total population | HIV + type 2 diabetes | Total population | HIV + type 2 diabetes | Total population | HIV + type 2 diabetes | Total population | HIV + type 2 diabetes | |
| Bacterial tryptophan metabolism | r = −0.29, p = 0.007 | r = −0.54, p = 0.012 | r = −0.47, p < 0.001 | r = −0.73, p < 0.001 | r = −0.03, p = 0.824 | r = −0.40, p = 0.083 | r = 0.12, p = 0.267 |
r = 0.29, p = 0.222 |
| KT-ratio | r = −0.25, p = 0.024 | r = −0.28, p = 0.216 | r = −0.22, p = 0.012 | r = −0.25, p = 0.824 | r = −0.24, p = 0.029 | r = −0.60, p = 0.006 | r = 0.45, p < 0.001 |
r = 0.56, p = 0.010 |
| Neopterin | r = −0.29, p = 0.008 | r = −0.40, p = 0.074 | r = −0.25, p = 0.020 | r = −0.31, p = 0.173 | r = −0.27, p = 0.014 | r = −0.40, p = 0.079 | r = 0.43, p < 0.001 |
r = 0.47, p = 0.037 |
| CRP | r = −0.30, p = 0.009 | r = −0.32, p = 0.166 | r = −0.29, p = 0.014 | r = −0.35, p = 0.135 | r = −0.21, p = 0.075 | r = −0.20, p = 0.409 | r = 0.15, p = 0.209 |
r = 0.30, p = 0.209 |
Data as Pearson correlations. Pearson correlations > 0.5 in bold. ADMA: Asymmetric dimethylarginine, CRP: C-reactive protein, KT: Kynurenin/Tryptophan. CRP-levels were log-transformed before correlation analyses.