Table 2.
Multivariate analysis of acute graft-versus-host disease (aGVHD).
| Factors | II–IV aGVHD |
|
|---|---|---|
| Univariate [p (HR)] | Multivariate [p (HR, 95% CI)] | |
| Patient age | ||
| ≤32 years >32 years |
0.866 (0.942) | 0.493 (1.299, 0.615–2.742) |
| Donor type | ||
| MSD HID |
0.447 (1.309) | 0.302 (1.521, 0.686–3.373) |
| Conditioning | ||
| Intensified Standard |
0.042 (2.083) | 0.849 (1.086, 0.462–2.556) |
| b-lactama | 0.037 (8.338, 1.137–61.118) | 0.039 (8.407, 1.118–63.237) |
| Vancomycin (intravenous) | 0.317 (1.441) | 0.584 (1.228, 0.589–2.557) |
| Microbial diversity Highb (inverse Simpson ≥2) Low (inverse Simpson <2) |
0.005 (2.759) | 0.029 (2.415, 1.092–5.340) |
ab-lactams, include carbapenem, cephalosporin, and b-lactam-b-lactamase combinations.
bMeasured by inverse Simpson index: high diversity ≥2; low diversity <2.
CI, confidence interval; HID, haploidentical donor; HR, hazard ratio; MSD, matched sibling donor.