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. 2018 Apr 24;10:119. doi: 10.3389/fnagi.2018.00119

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Copyright © 2018 Kim, Jeon, Kim, Koo and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SF inhibited loss of Parkinson’s disease (PD) related markers Parkin, PINK1 and DJ-1 in MPP⁺-induced SH-SY5Y cells. Cells were exposed to 1 mM MPP⁺ for 24 h in the absence or presence of 0.01 mg/mL SF for 24 h, then harvested and subjected to Western blotting using antibodies against Parkin, PINK1 and DJ-1 with whole cell lysate. MPP⁺ suppressed Parkin, PINK1 and DJ-1 expression, while SF enhanced them. Values are the means ± SD (n = 3). ^a–dMeans with different letters are significantly different (p < 0.05) by Duncan’s multiple-range test.