Fig. 6. Mechanistic overview of erythroid maintenance via Mtf2 repression of Wnt signaling.

In a wild-type erythroblast (left), Mtf2-PRC2 repression of important negative regulators of erythropoiesis and repression of canonical Wnt signaling results in proper erythroid maturation. In the absence of Mtf2 (right), de-repression of erythroid regulators and Wnt signaling results in a block in erythroid differentiation, which can be largely rescued by chemical inhibition of β-catenin