Table 7.

Linear contrasts of the differential effects of dietary n−6/n−3 ratio on the expression of APP and the glial marker GFAP, in the cerebral cortex of female mice under different reproductive conditions.

Protein	Main effects	p-value	95 % CI
A. APP	DI-DII (CO)	0.003	31.1, 128.3
	DI-DII (CO) - DI-II (OVX)	0.018	−154.2, −16.7
	DI-DII (CO) - DI-DII (OVX–E)	0.090	−127.4, 10.1
B. GFAP	DI-DII (CO)	0.012	16.7, 117.0
	DI-DII (CO) - DI-II (OVX)	0.029	−150.7, −9.0
	DI-DII (CO) - DI-DII (OVX–E)	0.344	−103.7, 38.1

The effect of diet under each reproductive status was calculated as percentage of variation induced by DII (Low n−6/n−3 ratio) vs. DI (High dietary n−6/n−3 ratio). CO: Intact, sham-operated female mice; OVX: Ovariectomized, placebo-treated; OVX-E: Ovariectomized, estradiol-treated. Data represented in Figure 4 were analyzed by 2 × 3 factorial ANOVA and saturated regression model; the most significant p-values and their corresponding 95% confidence intervals are highlighted.