Table 2.
Univariable analyses with regard to DFS and OS in 74 patients with ≥ pT3 in the surgery-alone group
| Factor | DFS | OS | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Sex (male/female) | 0.6 (0.2–1.2) | 0.155 | 0.6 (0.3–1.3) | 0.227 |
| Age | 0.7 (0.3–1.8) | 0.548 | 0.9 (0.4–2.0) | 0.805 |
| Tumor length (≤ 3/> 3 cm) | 0.9 (0.9–1.0) | 0.291 | 1.0 (0.9–1.0) | 0.264 |
| Localization (mid/distal) | 0.9 (0.6–1.3) | 0.721 | 0.9 (0.4–1.9) | 0.884 |
| Histology (SCC/AC) | 0.7 (0.4–1.5) | 0.450 | 0.6 (0.7–1.3) | 0.238 |
| pT stage (T3/T4) | 2.9 (1.0–8.3) | 0.047 | 4.0 (1.6–9.8) | 0.002 |
| pN1-3 | 1.7 (1.2–2.4) | 0.002 | 1.5 (1.1–2.1) | 0.004 |
| Differentiation grade (good/moderate vs. poor/signet cell/mucinous) | 0.8 (0.4–1.5) | 0.641 | 0.7 (0.4–1.4) | 0.367 |
| Perineural growth (present/absent) | 1.3 (0.7–2.3) | 0.411 | 1.0 (0.6–1.8) | 0.937 |
| Lymphovascular invasion (present/absent) | 1.1 (0.6–2.1) | 0.649 | 1.2 (0.7–2.1) | 0.491 |
| CRM (positive/negative) | 2.4 (1.4–4.3) | 0.002 | 2.0 (1.2–3.4) | 0.012 |
| EMVI (present/absent) | 1.4 (0.7–2.7) | 0.305 | 1.5 (0.8–2.7) | 0.236 |
| EMVI/N (nodal status) | 1.8 (1.3–2.6) | 0.001 | 1.8 (1.3–2.6) | < 0.001 |
| EMVI −/N − | Ref. | Ref. | ||
| EMVI +/N − | 1.8 (0.4–7.7) | 0.413 | 1.9 (0.4–8.0) | 0.377 |
| EMVI −/N + | 3.6 (1.4–9.3) | 0.008 | 3.9 (1.5–9.9) | 0.005 |
| EMVI +/N + | 6.1 (2.0–18.6) | 0.002 | 6.3 (2.1–18.3) | 0.001 |
Bold indicates p value < 0.2 in univariable analysis were included in the Cox regression multivariable analysis
DFS disease-free survival, OS overall survival, p pathological, CRM circumferential resection margin, EMVI extramural venous invasion, HR hazard ratio, CI confidence interval, SCC squamous cell carcinoma, AC adenocarcinoma