Table 2.
Composition of the AraQ regulons in 45 studied genomes of the Bifidobacteriaceace family.
| Gene/operon | Functional role(s) | No. a | Mode b |
|---|---|---|---|
| araQ | Global transcriptional regulator AraQ | 20 | R |
| araBDA | Ribulokinase; L-ribulose-5-phosphate 4-epimerase; L-arabinose isomerase | 35 | R |
| araE | Arabinose-proton symporter | 8 | R |
| abfE1 | α-L-arabinofuranosidase AbfE1, GH43 | 4 | ND |
| abfB2 | α-L-arabinofuranosidase AbfB2, GH51 | 3 | ND |
| araNtPtQt | α-AOS ABC transport system | 3 | ND |
| gap | Glyceraldehyde 3-phosphate dehydrogenase | 24 | A |
| eno | Enolase | 35 | A |
| pyk | Pyruvate kinase | 40 | A |
| tkt – tal | Transketolase; transaldolase | 24 | A |
| ldh | Lactate dehydrogenase | 20 | A |
| galM | Galactose mutarotase | 22 | R |
| pta – ackA | Phosphotransacetylase; acetate kinase | 8 | R |
| pflB – pflA | Pyruvate formate lyase | 10 | A |
| BL1113 | Aldo/keto reductase | 6 | R |
| malE | Maltose-binding periplasmic protein | 9 | A |
| malQ1 | 4-α-glucanotransferase | 4 | A? |
| maa | Maltose O-acetyltransferase | 7 | R |
| fucO | Lactaldehyde reductase | 7 | ND |
| glgB – Blon_ 1762–1763 | 1,4-α-glucan branching enzyme GlgB; two-component regulatory system | 6 | R |
| carD – ispF | CarD transcriptional regulator; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 6 | R |
| birA | Biotin-(acetyl-CoA-carboxylase) ligase | 6 | R |
| sixA | Phosphohistidine phosphatase | 5 | R |
| glk | Glucokinase, ROK family | 7 | A |
| bfrBCD – X – bfrR – bfrA | Fructosides ABC transport system; predicted transcriptional regulator; β-fructosidase | 4 | A |
aNumber of genomes in which a gene is regulated by AraQ. Detailed distribution of AraQ-regulated genes and AraQ-binding sites is given in Supplementary Table S1. bPredicted mode of AraQ-dependent regulation: A, activation; R, repression; ND, not determined.