Table 4.
Association of uNAG excretion with G/A ratio in subjects with type 1 diabetes.
| Variables | Univariate | P | Multivariate | P |
|---|---|---|---|---|
| Unadjusted β (95% CI) | Adjusted β (95% CI) | |||
| uNAG, log unit | 0.092 (0.018 to 0.166) | 0.015 | 0.103 (0.016 to 0.189) | 0.020 |
| Age, year | 0.001 (−0.058 to 0.060) | 0.971 | −0.001 (−0.005 to 0.004) | 0.761 |
| Women (vs. men) | 0.089 (−0.040 to 0.220) | 0.177 | 0.016 (−0.119 to 0.153) | 0.811 |
| BMI, kg/m2 | −0.030 (−0.051 to −0.008) | 0.005 | −0.028 (−0.049 to −0.007) | 0.007 |
| Diabetes duration, year | 0.105 (−0.024 to 0.234) | 0.112 | 0.173 (0.041 to 0.313) | 0.011 |
| uACR, log unit | 0.033 (−0.028 to 0.095) | 0.286 | −0.007 (−0.080 to 0.075) | 0.952 |
| Angiotensin blockers use (yes vs. no) | −0.121 (−0.300 to 0.058) | 0.185 | −0.212 (−0.417 to 0.005) | 0.055 |
| FPG, mg/dL | 0.014 (0.005 to 0.024) | 0.002 | 0.016 (0.006 to 0.025) | 0.002 |
| Hemoglobin, g/dL | −0.014 (−0.053 to 0.024) | 0.471 | 0.006 (−0.033 to 0.045) | 0.782 |
uNAG and uACR were log-transformed for linear regression models (log-uNAG and log-uACR). In multivariate model, β coefficient of uNAG for G/A ratio was reported with adjustment for age, sex, BMI, duration of diabetes, log-uACR, angiotensin blockers use, FPG, and hemoglobin. Bold characters represent statistically significant values. Abbreviations: uNAG, urinary N-acetyl-β-D-glucosaminidase; BMI, body mass index; uACR, urinary albumin-to-creatinine ratio.