Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 24;9:184. doi: 10.3389/fendo.2018.00184

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Wolfe and Hussain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mouse Kiss1 gene. Transcript variants of mouse Kiss1 are expressed from two different first exons, X3 (XM_006529681) and X4 (XM_006529682), that are regulated by cyclic AMP response element binding protein at a CRE (19). The transcriptional start site for Kiss1X3 and X4 is located in an exon of the Golt1a gene. Kiss1X1(XM_006529679) and X2 (XM_006529680) are regulated by ESR1 at an ERE (17). Kiss1 is a transcript including just the second and third exons (NM_178260.3). X1 and X3 include a larger second exon (including the shaded region) and X2 and X4 include a smaller second exon. All variants produce the KISS1 protein. KP-10 is the active region of all bioactive KISS1 peptides.