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. 2018 Apr 24;9:394. doi: 10.3389/fphar.2018.00394

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Copyright © 2018 Arora, Bhuria, Hazari, Pathak, Mathur, Roy, Sandhir, Soni, Dwarakanath and Bhatt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of DRDE-30 on bleomycin-induced oxidative-nitrative stress and cytogenetic damage. (A) Catalase activity. (B) SOD activity. (C) GSH level in the lung tissues of mice at day 06 post treatment. (D) MDA content in the lungs of mice at 06 days post treatment. (E) Expression level of 3-Nitrotyrosine in the lungs of mice as assessed by western blotting at 06 days post treatment. (F) Densitometric quantification after normalizing with β-actin. Results are expressed as mean ± SEM. (G) Micronuclei induction in lung tissues of mice at day 06 post treatment. Data represents mean ± SEM of two independent experiments with n = 3–5 per group per experiment. ^∗p < 0.05; ^∗∗p < 0.01.