Table 2.
Comparison of cell numbers for mononuclear phagocytes populations in murine models of polymicrobial sepsis, systemic inflammation, or endotoxemia.
| Reference | Model | Organ | pDC | Total CD11c+ cells | Monocytes and derivatives | cDC1-like | cDC2-like | DN |
|---|---|---|---|---|---|---|---|---|
| (85) | CLP | Spleen, peritoneum | ? | ➘ | ? | ? | ? | ? |
| (92) | CLP | Lymph nodes | ? | ➘ | ? | ? | ? | ? |
| (84) | CLP | Spleen | ? | ➘ | ? | ? | ? | ? |
| (93) | CLP | Lung | ? | ➘ | ? | ? | ? | ? |
| (88) | CLP | Lung | ➘ | ? | ? | ? | ➘ | ? |
| (86) | CLP | Spleen, lung | ? | ➘ | ? | ? | ? | ? |
| (94) | CLP | Spleen | ? | ➘ | ? | ➘ | ➘ | ✘ |
| (91) | CLP | Spleen, bone marrow | ? | ➘ | ? | ➘ | ➘ | ✘ |
| (89) | CLP | Spleen | ? | ➘ | ? | ➘ | ➘ | ➚ |
| (95) | CLP | Spleen | ? | ➘ | ? | ➘ | ➘ | ✘ |
| LPS injection | ? | ➘ | ? | ✘ | ➘ | ➚ | ||
| P3CSK4 injection | ? | ➘ | ? | ➚ | ➘ | ➚ | ||
| (96) | Escherichia coli infection | Spleen | ? | ➘ | ? | ➘ | ➘ | ➘ |
| LPS injection | ? | ➘ | ? | ➘ | ➘ | ➘ | ||
| (97) | Yersinia enterocolitica infection | Spleen | ? | ? | ➚ | ? | ? | ? |
| (98) | LPS injection | Spleen | ? | ? | ? | ➘ | ✘ | ? |
| (99) | LPS injection | Spleen | ? | ? | ➚ | ➘ | ➘ | ? |
Down or up arrows mean that the cell number is decreased or increased compared to controls, respectively. The cross means that the cell number is not significantly changed compared to controls. Cell numbers described here were measured within 24 h after injection for endotoxemia models or within a week after infection or surgery for CLP and systemic infection models. cDC1-like cells correspond to CD8+ or CD11b− DCs. cDC2-like cells correspond to CD11b+ or CD4+ DC. CLP, cecal ligation and puncture; pDC, plasmacytoid dendritic cells; cDC, conventionnal DC; DN, double negative DC for CD4 and CD8 markers; LPS, lipopolysaccharides.