Table 4. Effects of UA on brain in health and disease.

↓, Decrease; ↑, Increase; =, No change; MMP-9, Matrix metalloproteinase-9; BBB, blood-brain barrier; IL-1β, interleukin-1 beta; TNF-α, tumor necrosis factor-alpha; COX-2, cyclooxygenase-2; iNOS, inducible nitric oxide synthase; MMP-2, matrix metalloproteinase-2; IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; IL-6, interleukin-6; AGEs, advanced glycation end products; ROS, reactive oxygen species; GFAP, glial fibrillary acidic protein; RAGE, receptor for advanced glycation end-products; FoxO1, Forkhead box protein O1; HO-1, heme oxygenase; ATP, adenosine triphosphate; POMC, pro-opio melanocortin; JNK, c-Jun N-terminal kinase; APR, ATP production rate; ACTH, adrenocorticotrophic hormone; MDA, malondialdehyde; GSH, glutathione; GSSH, oxidized glutathione; SOD, superoxide dismutase; PPAR, peroxisome proliferator-activated receptors; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; p-Akt, phosphorylated protein kinase B.