Table 5. Effects of UA on liver in health and disease.

↓, Decrease; ↑, Increase; =, No change; ICAM-1, intracellular adhesion molecule; VEGF, vascular endothelial growth factor; ACC, acetyl-CoA carboxylase; ACO, acyl-CoA oxidase; AMPK, AMP-activated protein kinase; GSK 3β, glycogen synthase kinase 3 beta; SREBP, sterol regulatory element-binding protein; FAS, fatty acid synthase; CPT-1, carnitine palmitoyltransferase 1; DGAT1, diacylglycerol acyltransferase 1; TBARS, thiobarbituric acid reactive substances; GST, glutathione S-transferase; Nrf2, nuclear factor E2-related factor 2; HFD, high-fat diet; IGFBP 1, insulin-like growth factor (IGF) binding protein 1; p-Akt, phosphorylated protein kinase B; p-mTOR, phosphorylated mammalian target of rapamycin; PPAR, peroxisome proliferator-activated receptors; FAT, fatty acid translocase; CD36, cluster of differentiation 36; T-SOD, total superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; GSH, glutathione; HO-1, heme oxygenase; p-p38 MAPK, phosphorylated p38 mitogen-activated protein kinases; FOXO3, forkhead box O3; Bax, bcl-2-like protein 4; Bcl-2, B-cell lymphoma 2.