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. 2018 Mar 5;9(5):523–531. doi: 10.1111/1759-7714.12599

Figure 3.

Figure 3

Upregulated KCNQ1OT1 was correlated with tumor stage, tumor size, and ki67 expression. (a) The KCNQ1OT1 level was significantly higher in stage I (4.4‐fold, P = 0.006) and II (2.52‐fold, P = 0.024) lung cancer (LC) compared to normal tissue (P = 0.045). No significant change was observed between stage III LC and adjacent normal tissues. (b) No significant change in KCNQ1OT1 level was observed between lymph node metastasis and non‐metastasis (P = 0.135). (c) The KCNQ1OT1 level was significantly higher in tumors < 2 cm (P = 0.009). (d) The ki67 expression rate was lower in the KCNQ1OT1high (n = 65) than in the KCNQ1OT1low group (n = 65) (37.58 ± 18.87 vs. 26.50 ± 16.15; P = 0.045). (e) Scatterplots of correlation of KCNQ1OT1 expression level with Ki67 expression in LC (r = 0.679, P = 0.005). (f) Overall (hazard ratio [HR] = 0.78 (0.58–0.99), P = 0.000) and (g) disease‐free (HR = 0.86 [0.64–1.09]; P = 0.000) survival rates.