Table 4.

Studies evaluating the frequency of EML4‐ALK gene rearrangements in lung cancer

First author	Histological characteristics	Detection method	Population	Total number of patients	Number of EML4‐ALK positive patients	Percentage
Rodig et al.9	Adenocarcinoma	IHC, FISH	American (US)	358	20	5.6
Koivunen et al.7	NSCLC	RT‐PCR	American (US) (138), Korean (167)	305	8	2.6
Sequist et al.10	NSCLC	Multiplex RT‐PCR	White (503), Black (7), Asian (22)	546	27	4.9
Shaw et al.11	Enriched NSCLC	FISH	Non‐Asian (132), Asian (9)	141	19	13.5
Soda et al.4	NSCLC	RT‐PCR	Japanese	75	5	6.7
Inamura et al.6	Adenocarcinoma	RT‐PCR	Japanese	149	5	3.4
Takeuchi et al.14	Adenocarcinoma	Multiplex RT‐PCR	Japanese	253	11	4.3
Shinmura et al.12	NSCLC	RT‐PCR	Japanese	77	2	2.6
Takahashi et al.13	NSCLC	RT‐PCR	Japanese	313	5	1.6
Takeuchi et al.15	Adenocarcinoma	IHC, Multiplex RT‐PCR	Japanese	130	7	5.4
Present study	Adenocarcinoma in patients aged ≤50 years	Multiplex RT‐PCR	Japanese	49	5	10.2

FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; NSCLC, non‐small cell lung cancer; RT, reverse‐transcription.