Table 3.
Univariate and multivariate Cox proportional hazards regression analysis for prediction of OS and PFS
| Variable | OS HR (95.0% CI) | P | PFS HR (95.0% CI) | P |
|---|---|---|---|---|
| Univariate Cox proportional hazards regression analysis | ||||
| Age: < 60 vs. ≥ 60 | 0.479 (0.189–1.210) | 0.120 | 0.435 (0.205–0.922) | 0.030 |
| Gender: female vs. male | 1.437 (0.623–3.312) | 0.395 | 1.620 (0.805–3.261) | 0.176 |
| Smoking history: yes vs. no | 0.344 (0.146–0.808) | 0.014 | 0.314 (0.143–0.689) | 0.004 |
| ECOG PS: 0 vs. 1 | 0.294 (0.087–0.994) | 0.049 | 0.478 (0.206–1.107) | 0.085 |
| Tumor stage: IIIb vs. IV | 1.274 (0.378–4.294) | 0.696 | 1.342 (0.470–3.829) | 0.582 |
| Tumor size: < 3 vs. ≥ 3 cm | 1.523 (0.674–3.440) | 0.312 | 2.065 (1.000–4.267) | 0.050 |
| Mutation status: EGFR vs. ALK | 1.547 (0.519–4.609) | 0.434 | 1.930 (0.780–4.777) | 0.155 |
| Liver metastasis: yes vs. no | 0.491 (0.144–1.669) | 0.254 | 1.222 (0.371–4.022) | 0.742 |
| Bone metastasis: yes vs. no | 0.737 (0.330–1.646) | 0.456 | 0.761 (0.387–1.497) | 0.429 |
| Adrenal metastasis: yes vs. no | 3.121 (0.419–23.258) | 0.267 | 1.300 (0.397–4.260) | 0.665 |
| Baseline CTCs: < 8 vs. ≥ 8 | 2.739 (1.194–6.283) | 0.017 | 3.084 (1.357–7.011) | 0.007 |
| Stepwise multivariate Cox proportional hazards regression analysis | ||||
| Smoking history: yes vs. no | 0.227 (0.087–0.593) | 0.002 | 0.301 (0.135–0.669) | 0.003 |
| ECOG PS: 0 vs. 1 | 0.216 (0.058–0.805) | 0.022 | — | — |
| Baseline CTCs: < 8 vs. ≥ 8 | 3.317 (1.360–8.092) | 0.008 | 2.835(1.240–6.483) | 0.014 |
Bold value indicates P<0.05 are statistically significant. CI, confidence interval; CTCs, circulating tumor cells; ECOG PS, Eastern Cooperative Oncology Group performance status; HR, hazard ratio; OS, overall survival; PFS, progression‐free survival.