. 2018 Apr 11;5(5):ofy075. doi: 10.1093/ofid/ofy075

Table 4.

Linear Regression Analysis of the Association Between the NLRP3 rs10754558 SNP and IL-18, MCP-1, and IL-10 Levels in HIV/TB Co-infected Patients Initiating ART

	Time Point (n, n^a)	Mean (SD), log₁₀ pg/mL	Standardized Coefficient (SD)		Unstandardized Coefficient, log₁₀ pg/mL		R ²	P	Standardized Coefficient (SD)^a		Unstandardized Coefficient, log₁₀ pg/mL^a		R ^2a	P ^a
	Time Point (n, n^a)	Mean (SD), log₁₀ pg/mL	Beta	SE	Coeff	95% CI	R ²	P	Beta^a	SE^a	Coeff^a	95% CI^a	R ^2a	P ^a
IL-18	Pre-ART (93, 91^a)	3.05 (0.33)	0.20	0.10	0.13	0 to 0.27	0.039	.058	0.23	0.10	0.15	0.01 to 0.29	0.086	.033
	Week 4 post-ART (90, 88^a)	3.03 (0.38)	0.21	0.10	0.16	0.01 to 0.32	0.046	.043	0.24	0.11	0.18	0.02 to 0.35	0.111	.026
MCP-1	Pre-ART (93, 91^a)	2.74 (0.35)	0.22	0.10	0.15	0.01 to 0.30	0.035	.048	0.24	0.10	0.17	0.03 to 0.32	0.10	.020
	Week 4 post-ART (90, 88^a)	2.59 (0.23)	0.16	0.11	0.08	–0.02 to 0.18	0.027	.122	0.18	0.11	0.08	–0.02 to 0.18	0.076	.107
IL-10	Pre-ART (93, 91^a)	1.26 (0.45)	0.14	0.10	0.13	–0.06 to 0.31	0.021	.168	0.15	0.11	0.14	–0.06 to 0.33	0.035	.166
	Week 4 post-ART (90, 88^a)	1.32 (0.47)	0.28	0.10	0.26	0.07 to 0.46	0.079	.007	0.27	0.11	0.25	0.05 to 0.45	0.112	.013

Overall mean (standard deviation) IL-18, MCP-1, and IL-10, before and after ART initiation, are shown for the cohort. Two patients were missing HIV viral loads at week 4 post–ART initiation. Cytokine levels were log₁₀-transformed for approximate normalization for linear regression model.

Abbreviations: ART, antiretroviral therapy; Beta, standardized beta coefficient; CI, confidence interval; Coeff, unstandardized coefficient; n^a, number of patients with complete data for adjusted analysis; SNP, single nucleotide polymorphism; TB, tuberculosis.

^aAdjusted for CD4 count, HIV viral load, and time between antituberculosis therapy and ART initiation.