Fig. 9.

Injections of recombinant AIBP suppress vascular inflammation in vivo. Ldlr^−/− mice were fed a Western diet containing 1.25% cholesterol and 42% (kcal) fat for 4 weeks and iv injected with PBS, 0.5 µg of AIBP, or 0.5 µg of heat-inactivated (HI)-AIBP three times during last week of feeding. A: Body weight. B: Total plasma cholesterol before the start of injections (week 3) and in terminal blood (week 4). C: Plasma triglycerides. D: mRNA expression of inflammatory cytokines in whole aorta. Mean ± SEM; n = 3 or 4; ** P < 0.01; * P < 0.05 (one-way ANOVA). NS, not significant differences.