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. 2018 Mar 21;59(5):830–842. doi: 10.1194/jlr.M081851

Fig. 1.

Fig. 1.

Compounds AZ-1 and AZ-2 modulate ABCA1 and apoE in CCF-STTG1 cells. A: Chemical structures of compounds AZ-1 and AZ-2. B: CCF-STTG1 cells were treated with AZ-1 and AZ-2 using a seven-point concentration response performed at half-log intervals (0.03–30 μM) for 72 h. Data are expressed as percent apoE secretion relative to DMSO (0%) and 1 μM of the positive control LXR agonist, T0901317 (100%). Error bars represent range of duplicate wells in one representative assay. ABCA1 mRNA levels were measured by real-time qPCR (C) and cellular ABCA1 protein levels were measured by immunoblot in CCF-STTG1 cells after 72 h treatment with vehicle control DMSO, 1 μM T0901317, or 10 μM AZ-1 or AZ-2 (D). Graphs represent fold-change over DMSO control (dashed line) and ±95% confidence intervals from N independent experiments indicated in brackets. ***P < 0.001 compared with vehicle control using blocked two-way ANOVA post hoc tests.