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. 2018 Mar 21;59(5):830–842. doi: 10.1194/jlr.M081851

Fig. 5.

Fig. 5.

AZ-1 and AZ-2 exhibit P2X7 receptor antagonist activity. A: Concentration-dependent inhibition of Bz-ATP (100 μM) evoked responses by compound AZ-1 in HEK293 cells that stably overexpress the full-length human P2X7 receptor. The graph represents mean and SD from four cells. B: Concentration-dependent inhibition of Bz-ATP evoked responses by compound AZ-2. The graph represents mean and SD from five cells. C, D: Sample traces of whole-cell currents evoked by Bz-ATP (indicated by the arrow) in the absence or presence of a range of concentrations of AZ-1 or AZ-2.