Table 6.
Comparison of serum levels of amino acids (γmoles) and biogenic amines (γmoles) between the first-episode psychosis (FEP) patients (n = 36) at follow-up (FEPf) (after 7-month treatment with antipsychotics) and control subjects (CSs) (n = 37).
| Biomarkers | FEPf | CSs | Z-value | p-value | Effect size (η2) |
|---|---|---|---|---|---|
| Median (min–max) | Median (min–max) | ||||
| AMINO ACIDS | |||||
| Methionine (Met) | 12.5 (4.53–33.5) | 9.08 (4.43–35.2) | 2.27 | 0.02 | 0.07 |
| BIOGENIC AMINES | |||||
| Carnosine | 0.00 (0.00–0.15) | 0.00 (0.00–0.12) | −2.02 | 0.04 | 0.06 |
| Methionine-sulfoxide (Met-SO) | 8.72 (1.69–20.3) | 10.8 (3.04–23.1) | −2.26 | 0.02 | 0.07 |
| Met-SO/Methionine (Met) | 0.66 (0.05–3.55) | 1.44 (0.16–4.29) | −2.43 | 0.02 | 0.08 |
| Kyn/Tryptophan (Trp) | 0.04 (0.03–0.06) | 0.04 (0.03–0.05) | 3.09 | 0.002 | 0.13 |
Z-adjusted values according to Mann-Whitney U-test (FEPf compared to CSs).
Effect sizes were interpreted as moderate, with corresponding eta-squared ranging from 0.06 to 0.13.