Table 3.
Estimated Odds Ratios for the Associations Between Risk-of-Bias Judgements in Randomized Trials Included in the ROBES Study
| Risk-of-Bias Domain Pair | All Trials (n = 2,443) | All-Cause Mortality (n = 429) | Other Objective Outcome (n = 197) | “Semiobjective” Outcomea (n = 391) | Subjective Outcomeb (n = 1,426) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Sequence generation, allocation concealment | 10.4 | 8.6, 12.5 | 11.3 | 7.1, 17.9 | 16.7 | 7.9, 34.9 | 9.7 | 6.1, 15.4 | 9.5 | 7.4, 12.2 |
| Sequence generation, blinding | 2.5 | 2.2, 3.0 | 3.1 | 2.1, 4.6 | 2.0 | 1.0, 3.8 | 2.2 | 1.5, 3.3 | 2.8 | 2.2, 3.4 |
| Sequence generation, incomplete outcome data | 2.1 | 1.8, 2.4 | 2.7 | 1.8, 4.0 | 5.3 | 2.8, 9.8 | 1.7 | 1.1, 2.6 | 1.8 | 1.4, 2.2 |
| Allocation concealment, blinding | 2.9 | 2.4, 3.4 | 4.0 | 2.7, 6.0 | 6.0 | 3.0, 12.1 | 1.3 | 0.8, 1.9 | 3.2 | 2.6, 4.1 |
| Allocation concealment, incomplete outcome data | 2.2 | 1.8, 2.6 | 2.9 | 1.9, 4.4 | 4.4 | 2.4, 8.3 | 1.3 | 0.9, 2.0 | 2.0 | 1.6, 2.5 |
| Blinding, incomplete outcome data | 1.8 | 1.5, 2.1 | 1.8 | 1.2, 2.6 | 1.4 | 0.7, 2.6 | 2.1 | 1.4, 3.2 | 1.8 | 1.5, 2.3 |
Abbreviations: CI, confidence interval; OR, odds ratio; ROBES, Risk of Bias in Evidence Synthesis.
a Outcomes for which ascertainment is accurate but their occurrence is influenced by a patient’s or health-care provider’s subjective judgement (e.g., duration of hospital stay, admissions, withdrawals, cesarean delivery).
b Includes meta-analyses in which some trials had subjective measures and some objective measures (e.g., self-reports and laboratory measures).