Figure 6.

Principal coordinate analysis (PCoA) of transcriptomes overlaid with distinguishing metabolites. A PCoA with the Bray–Curtis similarity statistic was performed on the transcriptome dataset. Transcriptome counts were normalized by total number of gene counts per sample. Metabolites were normalized by total sum intensity per sample and were chosen based on best distinguishing each sample from each other. Metabolites included are threonine, oxoproline, methionine, lysine, leucine, isoleucine, hydroxylamine, histidine, glycine and alanine. 2,3-butanediol = PaFLR01 + 20 mM 2,3-butanediol. Lactic acid = PaFLR01 + 20 mM lactic acid.