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. 2018 Apr 24;9:397. doi: 10.3389/fphar.2018.00397

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Copyright © 2018 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó-Ollé, Cilleros-Mañé and Just-Borràs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagrams showing relations of AR with mAChR and TrkB receptors. In (A), synergistic and antagonistic roles of the AR, mAChR and TrkB receptor during development. AR are necessary to modulate axonal loss and several synergistic (green arrows) and antagonistic (red arrows) relations are clearly observed between all receptors, which affect synapse elimination. In (B), the diagram indicates that the functional integrity of the AR favors the normal operation of the mAChR and the TrkB pathways in the control of the neurotransmitter release in the adulthood.