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. 2018 Apr 11;81(4):966–975. doi: 10.1021/acs.jnatprod.7b01070

Scheme 1. Natural Products from Red Clover, Soy, Hops, and Licorice.

Scheme 1

Genistein (1) is an ERβ-selective compound from red clover and soy. 8-Prenylnaringenin (2) is a potent estrogenic compound from hops. 8-Prenylapigenin (3) is an ERβ-selective compound isolated from licorice (G. inflata). Abyssinone II (4), licochalcone C (5), and licochalcone A (6) are isolated compounds from G. inflata with no estrogenic activity. Liquiritigenin (7) and isoliquiritigenin (8) are the estrogenic pair isolated from various licorice extracts.