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. 2018 Apr 3;3(4):3717–3736. doi: 10.1021/acsomega.8b00409

Scheme 7. Click-Ready ABTD Construct 6.

Scheme 7

Reaction conditions and yields: (i) 9 (10 equiv), tris(2-carboxyethyl)phosphine (TCEP) (3 equiv), MeOH, 25 °C, 24 h, 49%; (ii) 10 (0.5 equiv), TCEP (3 equiv), MeOH/H2O (1/1), 25 °C, 24 h, 49%.