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. 2018 Apr 24;9:848. doi: 10.3389/fimmu.2018.00848

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Copyright © 2018 Pouw, Gómez Delgado, López Lera, Rodríguez de Córdoba, Wouters, Kuijpers and Sánchez-Corral.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic variants associated with the CFHR3*A and CFHR3*B alleles. (A) Exon–intron structure of the CFHR3 gene showing the location of the genetic variants within exon 1 (rs385390; rs446868) and exon 5 (rs138675433; rs149352569) that tag the CFHR3*A and CFHR3*B alleles. (B) In silico data of gene expression correlations from the GTExPortal show that individuals who are homozygous for the rs385390 A variant present lower mRNA expression in liver tissue than individuals homozygous for the rs385390 C variant, or than heterozygous individuals. Number of individuals with each genotype is shown between brackets. GTExPortal: Portal for the Genotype-Tissue Expression project (https://www.gtexportal.org). GTExPortal is supported by the Common Fund of the National Institutes of Health. The data in panel (B) were obtained on October 2017.